Stereoselective Synthesis of Macrolide and Polyether Antibiotics
نویسندگان
چکیده
منابع مشابه
Optimization of streptomycete strains producing polyether and macrolide antibiotics.
screened for high-frequency transfer of OTC resistance. Although such strains were found at quite a high frequency (about 1 in IOOO), it was subsequently discovered that a second plasmid SRP2 had actually been primed. This possessed much weaker sex-factor activity than SRPl . Neither plasmid has proved amenable to physical isolation or analysis, and with the advent of recombinant DNA techniques...
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groups activated under the treatment with diphenyl phosphorazidate7) and triethylamine or N,N'-dicyclohexylcarbodiimide and I-hydroxy1 H-benzotriazole mixtures. The reaction was carried out in N,N-dimethylformamide or N,Ndimethylacetamide, at room temperature, using an excess of the reagents. The course of the reaction was followed by means of thin-layer chromatography on silica gel with the so...
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Five novel 3-hydroxyl derivatives of sixteen-membered macrolide possessing 4-O-acyl-alpha-L-cladinose as a neutral sugar moiety were synthesized by using a combination of structurally stable silyl acetal protection and selective hydrogenolysis of a 3"-methylthiomethyl ether to a 3"-OMe group. Several derivatives having n-butyryl, i-butyryl and n-valeryl substituent at the 4"-OH group exhibited ...
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Noboritomycins A and B, two new polycyclic ionophoric polyethers were isolated from a strain of Streptomyces noboritoensis. The crystal structure and absolute configuration of noboritomycin A were established by X-ray analysis of its silver salt C43/63O14Ag. Noboritomycin A is the first metabolic polyether possessing two carboxylic acid functions on the carbon backbone (C-31), namely a free aci...
متن کاملMacrolide antibiotics and pulmonary inflammation.
Many clinically effective therapeutic agents can exhibit localized and systemic effects that are manifestly different from their intended primary pharmacological mode of action. Macrolide antibiotics such as erythromycin and its derivatives are no exception. In addition to their antibacterial action, this class of antibiotics exhibits anti-inflammatory activity in a variety of airway diseases s...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1990
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.110.8_523